Role of the Hippo pathway and mechanisms for controlling cellular localization of YAP/TAZ

Hyeryun Kwon, Jiyoung Kim, Eek hoon Jho

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

The Hippo pathway is a crucial signaling mechanism that inhibits the growth of cells and organs during development and in disease. When the Hippo pathway is activated, YAP/TAZ transcriptional coactivators are phosphorylated by upstream kinases, preventing nuclear localization of YAP/TAZ. However, when the Hippo pathway is inhibited, YAP/TAZ localize mainly in the nucleus and induce the expression of target genes related to cell proliferation. Abnormal proliferation of cells is one of the hallmarks of cancer initiation, and activation of Hippo pathway dampens such cell proliferation. Various types of diseases including cancer can occur due to the dysregulation of the Hippo pathway. Therefore, a better understanding of the Hippo pathway signaling mechanisms, and in particular how YAP/TAZ exist in the nucleus, may lead to the identification of new therapeutic targets for treating cancer and other diseases. In this review, we summarize the overall Hippo pathway and discuss mechanisms related to nuclear localization of YAP/TAZ.

Original languageEnglish
Pages (from-to)5798-5818
Number of pages21
JournalFEBS Journal
Volume289
Issue number19
DOIs
StatePublished - Oct 2022

Keywords

  • Hippo pathway
  • TEAD
  • YAP/TAZ
  • cancer
  • nuclear–cytoplasmic shuttling

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