Synthesis and characterization of surface-initiated helical polyisocyanopeptide brushes

Eunhee Lim, Guoli Tu, Erik Schwartz, Jeroen J.L.M. Cornelissen, Alan E. Rowan, Roeland J.M. Nolte, Wilhelm T.S. Huck

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


This article describes the first surface-initiated polymerization of isocyanide monomers onto various surfaces in a controlled manner. Brushes up to 200 nm could be easily obtained within 3 h of polymerization, and the polymer growth was studied as a function of reaction time, monomer concentration, and growth conditions, using atomic force microscopy (AFM) and ellipsometry. The monomers used in this study contain dipeptide (L,L-Ala-Ala) side groups; circular dichroism (CD) measurements, Fourier transform infrared spectroscopy (FTIR), and AFM confirmed that the well-defined helical conformation was retained in the polyisocyanide brushes with hydrogen bonds along the polymer chains.

Original languageEnglish
Pages (from-to)1945-1951
Number of pages7
Issue number6
StatePublished - 25 Mar 2008


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