Tear clearance rate in dogs: Measurement using anterior segment optical coherence tomography

Hyun Jeong Yoon, Sangshin Park, Joon Young Kim

Research output: Contribution to journalArticlepeer-review


Objective: The tear clearance rate (TCR), determined using anterior segment optical coherence tomography (AS-OCT) images, and its correlation with ocular surface parameters, including blink rate, Schirmer tear test-1 (STT-1) and tear film breakup time (TFBUT), were evaluated. Animals studied: Left eyes of 20 client-owned dogs with no ocular disease symptoms. Procedures: The tear meniscus height (TMH) was evaluated using AS-OCT images before the instillation of 5 μL saline (TMHbase), immediately post-instillation (TMH0), 30-s post-instillation (TMH0.5) and at 1 min intervals for 5 min post-instillation (TMH1, TMH2, TMH3, TMH4 and TMH5). The TCR was calculated using the formula [(TMH0 − TMH0.5)/TMH0]×100 (%). The eyes were classified into two groups with the median: ‘High TMHbase’ (n = 10) and ‘Low TMHbase’ (n = 10). Eyes with STT-1 values ≥15 mm/min and TFBUT ≥ 12 s were assigned to the ‘Satisfied’ subgroup, whereas eyes not satisfying these criteria were assigned to the ‘Not satisfied’ subgroup. Results: TMH0 was higher than TMH0.5 (p = 0.02), wherein TMH0.5 to TMH5 did not differ significantly. The TCR and blink rate were negatively correlated (p = 0.02). The ‘Not satisfied’ subgroup in the low TMHbase group had a lower TCR (p = 0.02) and higher blink rate (p = 0.04) than the ‘Satisfied’ subgroup. Conclusions: TCR can be evaluated using AS-OCT in dogs. Eyes with a lower TCR blink more frequently. TMH merits studying to understand ocular surface health.

Original languageEnglish
Article numbere1334
JournalVeterinary Medicine and Science
Issue number1
StatePublished - Jan 2024


  • Schirmer tear test-1
  • blink rate
  • dry eye syndrome
  • tear clearance rate
  • tear film breakup time
  • tear meniscus height


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