TY - JOUR
T1 - Terahertz imaging of excised oral cancer at frozen temperature
AU - Sim, Yookyeong Carolyn
AU - Park, Jae Yeon
AU - Ahn, Kang Min
AU - Park, Chansik
AU - Son, Joo Hiuk
PY - 2013
Y1 - 2013
N2 - The feasibility of terahertz (THz) imaging at frozen temperature for the clinical application of oral cancer detection was investigated by analyzing seven oral tissues resected from four patients. The size, shape, and internal position of the oral cancers were mapped by THz radiation in the frequency range of 0.2-1.2 THz at -20 °C and 20 °C, and compared with those identified in the histological examination. THz imaging of frozen tissue was found to offer greater sensitivity in distinguishing cancerous areas from surrounding tissue and a larger THz-frequency spectral difference between the oral cancer and normal mucosa than room-temperature THz imaging. A cancerous tumor hidden inside tissue was also detected using this method by observing the THz temporal domain waveform. The histological analysis showed that these findings resulted from cell structure deformations involving the invasion of oral tumor and neoplastic transformations of mucous cells. Therefore, a cytological approach using THz radiation at a frozen temperature might be applied to detect oral cancer.
AB - The feasibility of terahertz (THz) imaging at frozen temperature for the clinical application of oral cancer detection was investigated by analyzing seven oral tissues resected from four patients. The size, shape, and internal position of the oral cancers were mapped by THz radiation in the frequency range of 0.2-1.2 THz at -20 °C and 20 °C, and compared with those identified in the histological examination. THz imaging of frozen tissue was found to offer greater sensitivity in distinguishing cancerous areas from surrounding tissue and a larger THz-frequency spectral difference between the oral cancer and normal mucosa than room-temperature THz imaging. A cancerous tumor hidden inside tissue was also detected using this method by observing the THz temporal domain waveform. The histological analysis showed that these findings resulted from cell structure deformations involving the invasion of oral tumor and neoplastic transformations of mucous cells. Therefore, a cytological approach using THz radiation at a frozen temperature might be applied to detect oral cancer.
UR - http://www.scopus.com/inward/record.url?scp=84883359358&partnerID=8YFLogxK
U2 - 10.1364/BOE.4.001413
DO - 10.1364/BOE.4.001413
M3 - Article
AN - SCOPUS:84883359358
SN - 2156-7085
VL - 4
SP - 1413
EP - 1421
JO - Biomedical Optics Express
JF - Biomedical Optics Express
IS - 8
ER -