TY - JOUR
T1 - The effect of remote ischemic pre-conditioning on pulmonary vascular pressure and gas exchange in healthy humans during hypoxia
AU - Kim, Chul Ho
AU - Sajgalik, Pavol
AU - Van Iterson, Erik H.
AU - Jae, Sae Young
AU - Johnson, Bruce D.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/3
Y1 - 2019/3
N2 - This study investigated whether rIPC alters the typical changes in pulmonary arterial pressure, pulmonary gas exchange associated with exercise in hypoxia. Methods: 16 healthy adults were randomized to either rIPC treatment (n = 8) or control (n = 8). Afterward, subjects performed supine ergometry at constant load (30 W, 40˜50 rpm) for 25 min during hypoxia (12.5% O 2 ). Following a 90˜120 min rest, either rIPC or sham treatment was performed, which was then followed by post-assessment exercise. Throughout exercise, pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (mPAP) were measured via echocardiography, while pulmonary gas exchange was being assessed. Results: The rICP group demonstrated improved PASP and mPAP (p < 0.05), whereas the control group did not. Additionally, breathing efficiency (V E /V CO2 ) and end-tidal CO 2 (PET CO2 ) were improved in rIPC group (p < 0.05), but not in controls. Conclusion: These data suggest that rIPC contributes to reduced pulmonary arterial pressure, and improved pulmonary gas exchange during hypoxic exercise. However, follow-up studies are needed to apply these findings to patient care settings.
AB - This study investigated whether rIPC alters the typical changes in pulmonary arterial pressure, pulmonary gas exchange associated with exercise in hypoxia. Methods: 16 healthy adults were randomized to either rIPC treatment (n = 8) or control (n = 8). Afterward, subjects performed supine ergometry at constant load (30 W, 40˜50 rpm) for 25 min during hypoxia (12.5% O 2 ). Following a 90˜120 min rest, either rIPC or sham treatment was performed, which was then followed by post-assessment exercise. Throughout exercise, pulmonary arterial systolic pressure (PASP) and mean pulmonary arterial pressure (mPAP) were measured via echocardiography, while pulmonary gas exchange was being assessed. Results: The rICP group demonstrated improved PASP and mPAP (p < 0.05), whereas the control group did not. Additionally, breathing efficiency (V E /V CO2 ) and end-tidal CO 2 (PET CO2 ) were improved in rIPC group (p < 0.05), but not in controls. Conclusion: These data suggest that rIPC contributes to reduced pulmonary arterial pressure, and improved pulmonary gas exchange during hypoxic exercise. However, follow-up studies are needed to apply these findings to patient care settings.
KW - Breathing efficiency
KW - Low oxygen
KW - Pulmonary pressure
KW - rIPC
UR - http://www.scopus.com/inward/record.url?scp=85060291034&partnerID=8YFLogxK
U2 - 10.1016/j.resp.2019.01.008
DO - 10.1016/j.resp.2019.01.008
M3 - Article
C2 - 30658096
AN - SCOPUS:85060291034
SN - 1569-9048
VL - 261
SP - 62
EP - 66
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
ER -