Toward cancer treatment using terahertz radiation: Demethylation of cancer cells

Joo Hiuk Son, Hwayeong Cheon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.

Original languageEnglish
Title of host publicationNext-Generation Spectroscopic Technologies XIII
EditorsLuisa T. M. Profeta, Abul K. Azad, Steven M. Barnett
PublisherSPIE
ISBN (Electronic)9781510635579
DOIs
StatePublished - 2020
EventNext-Generation Spectroscopic Technologies XIII 2020 - None, United States
Duration: 27 Apr 20208 May 2020

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11390
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceNext-Generation Spectroscopic Technologies XIII 2020
Country/TerritoryUnited States
CityNone
Period27/04/208/05/20

Keywords

  • Biomedical
  • Cancer diagnosis
  • Cancer therapy
  • Methylation
  • Terahertz

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