Toward cancer treatment using terahertz radiation: Demethylation of cancer cells

Joo Hiuk Son; Hwayeong Cheon

doi:10.1117/12.2557655

Toward cancer treatment using terahertz radiation: Demethylation of cancer cells

Joo Hiuk Son
, Hwayeong Cheon

Department of Physics

University of Seoul

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.

Original language	English
Title of host publication	Next-Generation Spectroscopic Technologies XIII
Editors	Luisa T. M. Profeta, Abul K. Azad, Steven M. Barnett
Publisher	SPIE
ISBN (Electronic)	9781510635579
DOIs	https://doi.org/10.1117/12.2557655
State	Published - 2020
Event	Next-Generation Spectroscopic Technologies XIII 2020 - None, United States Duration: 27 Apr 2020 → 8 May 2020

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11390
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Next-Generation Spectroscopic Technologies XIII 2020
Country/Territory	United States
City	None
Period	27/04/20 → 8/05/20

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biomedical
Cancer diagnosis
Cancer therapy
Methylation
Terahertz

Access to Document

10.1117/12.2557655

Cite this

@inproceedings{81e56d0c872c4f41b99773d08e495e4b,

title = "Toward cancer treatment using terahertz radiation: Demethylation of cancer cells",

abstract = "Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.",

keywords = "Biomedical, Cancer diagnosis, Cancer therapy, Methylation, Terahertz",

author = "Son, \{Joo Hiuk\} and Hwayeong Cheon",

note = "Publisher Copyright: {\textcopyright} 2020 SPIE; Next-Generation Spectroscopic Technologies XIII 2020 ; Conference date: 27-04-2020 Through 08-05-2020",

year = "2020",

doi = "10.1117/12.2557655",

language = "English",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Profeta, \{Luisa T. M.\} and Azad, \{Abul K.\} and Barnett, \{Steven M.\}",

booktitle = "Next-Generation Spectroscopic Technologies XIII",

address = "United States",

}

Son, JH & Cheon, H 2020, Toward cancer treatment using terahertz radiation: Demethylation of cancer cells. in LTM Profeta, AK Azad & SM Barnett (eds), Next-Generation Spectroscopic Technologies XIII., 113900Z, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11390, SPIE, Next-Generation Spectroscopic Technologies XIII 2020, None, United States, 27/04/20. https://doi.org/10.1117/12.2557655

Toward cancer treatment using terahertz radiation: Demethylation of cancer cells. / Son, Joo Hiuk; Cheon, Hwayeong.
Next-Generation Spectroscopic Technologies XIII. ed. / Luisa T. M. Profeta; Abul K. Azad; Steven M. Barnett. SPIE, 2020. 113900Z (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11390).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Toward cancer treatment using terahertz radiation

T2 - Next-Generation Spectroscopic Technologies XIII 2020

AU - Son, Joo Hiuk

AU - Cheon, Hwayeong

PY - 2020

Y1 - 2020

N2 - Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.

AB - Carcinogenesis involves DNA methylation, a primary alteration in DNA, in the development of cancer before genetic mutation. Because abnormal DNA methylation is found in most cancer cells, the assessment and manipulation of DNA methylation using terahertz radiation can be a novel optical method to detect and control cancer. By directly observing the methylation via terahertz spectroscopy at approximately 1.65 THz, this epigenetic chemical change can be manipulated to the state of demethylation using high-power terahertz radiation. Demethylation of cancer DNA is a key issue in epigenetic cancer therapy, and our results may lead to the treatment of cancer using electromagnetic waves.

KW - Biomedical

KW - Cancer diagnosis

KW - Cancer therapy

KW - Methylation

KW - Terahertz

UR - https://www.scopus.com/pages/publications/85086898892

U2 - 10.1117/12.2557655

DO - 10.1117/12.2557655

M3 - Conference contribution

AN - SCOPUS:85086898892

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Next-Generation Spectroscopic Technologies XIII

A2 - Profeta, Luisa T. M.

A2 - Azad, Abul K.

A2 - Barnett, Steven M.

PB - SPIE

Y2 - 27 April 2020 through 8 May 2020

ER -

Toward cancer treatment using terahertz radiation: Demethylation of cancer cells

Abstract

Publication series

Conference

UN SDGs

Keywords

Access to Document

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