Tunable growth factor release from nano-assembled starch multilayers

Younghyun Cho, Jong Bum Lee, Jinkee Hong

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We report the preparation and characterization of polysaccharide-based nano-assembled surface coatings. Chitosan and fibroblast growth factor-2 (FGF-2) were assembled with starch through electrostatic layer-by-layer assembly. The chitosan/starch/FGF-2/starch nano-assembly surface coatings were formed via sequential adsorption of positively-charged chitosan and FGF-2 aqueous solutions and negatively-charged starch, with the process monitored by a profilometer. SEM was used to investigate the surface morphology and growth of multilayer coatings as a function of the number of bilayers. In addition, annealing of the multilayer structure induced physical reorganization of the starch granules. The FGF-2 release profile could be controlled by altering the microstructure of the starch. We expect that this demonstration of starch-based controlled release of growth factor will offer a new route to nano-assembly of truly biocompatible starch-based controlled-release surface coatings.

Original languageEnglish
Pages (from-to)32-36
Number of pages5
JournalChemical Engineering Journal
StatePublished - 1 Apr 2013


  • Controlled release
  • Layer-by-layer
  • Microstructure
  • Multilayer
  • Nano-assembly
  • Starch


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