Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β

Yelim Yi; Jiyeon Han; Min Hee Park; Nahye Park; Eunju Nam; Hee Kyung Jin; Jae Sung Bae; Mi Hee Lim

doi:10.1039/c9cc01005j

Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β

Yelim Yi, Jiyeon Han, Min Hee Park, Nahye Park, Eunju Nam, Hee Kyung Jin, Jae Sung Bae, Mi Hee Lim

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-β [Zn(ii)-Aβ], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Aβ (phen, 1, and 2), or both (3).

Original language	English
Pages (from-to)	5847-5850
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	42
DOIs	https://doi.org/10.1039/c9cc01005j
State	Published - 2019

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abstract = "We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-β [Zn(ii)-Aβ], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Aβ (phen, 1, and 2), or both (3).",

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AU - Yi, Yelim

AU - Han, Jiyeon

AU - Park, Min Hee

AU - Park, Nahye

AU - Nam, Eunju

AU - Jin, Hee Kyung

AU - Bae, Jae Sung

AU - Lim, Mi Hee

PY - 2019

Y1 - 2019

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AB - We report a new series of small molecules able to achieve the tunability of modulatory activities against acid sphingomyelinase (ASM) and Zn(ii)-bound amyloid-β [Zn(ii)-Aβ], two pathological targets found in the brain affected by Alzheimer's disease. Rational tuning of the hydrophobicity and Zn(ii) binding affinity of the 1,10-phenanthroline (phen) framework successfully yielded compounds as chemical modulators for ASM (4 and 5), Zn(ii)-Aβ (phen, 1, and 2), or both (3).

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SN - 1359-7345

VL - 55

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EP - 5850

JO - Chemical Communications

JF - Chemical Communications

IS - 42

ER -

Tunable regulatory activities of 1,10-phenanthroline derivatives towards acid sphingomyelinase and Zn(ii)-amyloid-β

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