Viscosity-regulated control of rna microstructure fabrication

Sunghyun Moon, Hyejin Kim, Dajeong Kim, Jong Bum Lee

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The development of RNA self-assemblies offers a powerful platform for a wide range of biomedical applications. The fabrication process has become more elaborate in order to achieve functional structures with maximized potential. As a facile means to control the structure, here, we report a new approach to manipulate the polymerization rate and subsequent self-assembly process through regulation of the reaction viscosity. As the RNA polymerization rate has a dependence on solution viscosity, the resulting assembly, crystallization, and overall sizes of the product could be manipulated. The simple and precise control of RNA polymerization and self-assembly by reaction viscosity will provide a way to widen the utility of RNA-based materials.

Original languageEnglish
Article number454
Pages (from-to)1-9
Number of pages9
Issue number3
StatePublished - 1 Feb 2021


  • Crystallization
  • RNA microstructures
  • RNA self-assemblies
  • Reaction control
  • Viscosity


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