Whole-Proteome Differential Screening Identifies Novel Vaccine Candidates for Schistosomiasis japonica

Hannah W. Wu, Sangshin Park, Sunthorn Pond-Tor, Ron Stuart, Sha Zhou, Yang Hong, Amanda E. Ruiz, Luz Acosta, Blanca Jarilla, Jennifer F. Friedman, Mario Jiz, Jonathan D. Kurtis

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Schistosomiasis remains a leading cause of chronic morbidity in endemic regions despite decades of widespread mass chemotherapy with praziquantel. Using our whole proteome differential screening approach, and plasma and epidemiologic data from a longitudinal cohort of individuals living in a Schistosoma japonicum-endemic region of the Philippines, we interrogated the parasite proteome to identify novel vaccine candidates for Schistosoma japonicum. We identified 16 parasite genes which encoded proteins that were recognized by immunoglobulin G or immunoglobulin E antibodies in the plasma of individuals who had developed resistance to reinfection, but were not recognized by antibodies in the plasma of individuals who remained susceptible to reinfection. Antibody levels to Sj6-8 and Sj4-1 measured in the entire cohort (N†=†505) 1 month after praziquantel treatment were associated with significantly decreased risk of reinfection and lower intensity of reinfection over 18 months of follow-up.

Original languageEnglish
Pages (from-to)1265-1274
Number of pages10
JournalJournal of Infectious Diseases
Volume223
Issue number7
DOIs
StatePublished - 1 Apr 2021

Keywords

  • Schistosoma japonicum
  • cohort
  • differential screening
  • schistosomiasis; proteome
  • vaccine

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